RNAi and RNA Reagents

Control products, reagents, and RNA samples for use in the study of RNA and the process of RNA interference (RNAi or post-transcriptional gene silencing).

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1,036 – 1,050 of 2,692 results

1,036

Genscript Corporation GLP-1R mFc Chimera Human

The GLP1R a GPCR is found on pancreatic beta cells and brain neurons It regulates blood sugar by enhancing insulin secretion In humans it is encoded by the gene GLP1R on chromosome 6 GLP1R is part of the glucagon receptor GPCR family and comprises an extracellular domain that binds the C-terminal helix of GLP-1 and a transmembrane domain that binds the N-terminal region of GLP-1 The TMD domain contains polar residues that regulate biased signaling while the transmembrane helical boundaries and extracellular surface trigger biased agonism

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1,037

Genscript Corporation CD160 Fc Chimera Human

CD160 is a glycosylphosphatidylinositol-anchored Ig domain protein that is expressed on almost all intestinal intraepithelial lymphocytes (IELs) T (gamma delta T) cells NK (natural killer) cells and a minor subset of CD4 and CD8 T cells In terms of function work has centered on the role of CD160 in enhancing NK or CD8 T cell activation Such effects have been attributed to the ability of CD160 to bind classical and nonclassical MHC class I molecules although with apparent low affinity requiring clustering of MHC class I molecules or overexpression of CD160 or MHC class I for detection of the interaction

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1,038

Genscript Corporation IL-17R alpha/CD217 hFc Chimera

Interleukin 17 (also known as CTLA 8) is a T cell expressed pleotropic cytokine IL 17 binds to IL 17 receptor (IL 17 R) which shares no homology with any known family of receptors While the expression of IL 17 is restricted to activated T cells the IL 17 R mRNA exhibits a broad tissue distribution and has been detected in virtually all cells and tissues tested The human IL 17 R gene was localized to chromosome 22

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1,039

Genscript Corporation PD-L1 Fc Chimera Mouse

Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene PD-L1 is a 40 kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy tissue allografts autoimmune disease and other disease states such as hepatitis Normally the immune system reacts to foreign antigens where there is some accumulation in the lymph nodes or spleen which triggers a proliferation of antigen-specific CD8 T cell The formation of PD-1 receptor / PD-L1 or B7 1 receptor /PD-L1 ligand complex transmits an inhibitory signal which reduces the proliferation of these CD8 T cells at the lymph nodes and supplementary to that PD-1 is also able to control the accumulation of foreign antigen specific T cells in the lymph nodes through apoptosis which is further mediated by a lower regulation of the gene Bcl-2 PD-L